HANSRAJ (ADIANTUM CAPILLUS VENERIS LINN.): A SYSTEMATIC REVIEW ON ITS ETHNOBOTANY, PHYTOCHEMICAL AND PHARMACOLOGICAL PROFILE

Adiantum capillus-veneris Linn. of Adiantaceae family is one of most common plants that have found diverse medicinal uses in the indigenous systems of medicine. It has been used in cold, skin diseases, bronchitis, hair fall and inflammatory diseases. It is also considered as tonic and diuretic. The previous studies showed that Adiantum capillus veneris contained many secondary metabolites and exerted antimicrobial, antiinflammatory, analgesic, hypoglycemic, antioxidant,  antiproliferative, antidermatitis, neuroprotective, anticholesterolemic and many other effects. The present review will highlight the chemical constituents and the pharmacological and therapeutic effects of Adiantum capillus veneris. A wide range of chemical compounds  including adiantone,  diplopterol, kaempferol, naringin, neoxanthin, populnin, quinic acid, rhodoxanthin, rutin, shikimic acid,  zeaxanthin etc. have been isolated from this plant. The plant leaves and stem of Adiantum capillus veneris L. were found to contain higher amount of triterpenoids and flavonoids. Adiantum capillus-veneris L., is nowadays gaining interest by the scientific researchers due to its folklorics and because of its therapeutic value, easy availability and degree of research work which is not done.  The present review aims at reviewing the research works undertaken till date, on this plant in order to provide sufficient baseline information for future works and for commercial   exploitation. The opening of a wide venue for further research and translation into clinical settings is also envisaged

Antioxidant potentials and quality aspects of Jamun (Syzygium cumini L.) supplemented unleavened flat bread (Indian chapatti)

Enriched chapattis prepared by supplementing whole wheat flour with Jamun (Syzygium cumini L.) pulp at 5, 10 and 15% were assessed for antioxidant activity and quality. Jamun pulp supplementation enhanced the bioactive composition of chapatti in terms of increased anthocyanins, total phenols and antioxidant activity. Total phenolic content and antioxidant activity increased 99.73% and 44.38%, respectively after incorporation of Jamun pulp (15%) to whole wheat flour Indian chapatti. Anthocyanins were not observed in control chapatti and in Jamunsupplemented chapatti the range was 1.41-2.64 mg/100g content for 5-15% supplementation level. Qualitative evaluation revealed non-sticky behavior of dough supplemented with Jamun at 5 and 10% level and slight stickiness at 15% level. Chapattis exhibited full puffing at all supplementation levels. Sensory scores were highest for 10% Jamun supplemented chapatti. Crude fiber content improved significantly (13.77% increase) in chapattis on supplementation of Jamun pulp. The study concluded that supplementation of wheat flour with Jamun pulp improved nutritional and antioxidant status of chapatti

Studies on Aloe Juice Supplemented Kinnow Nectar

Abstrac

long term outcomes of pediatric patients with malignant and non malignant disorders receiving α β t cell depleted hla haploidentical hematopoietic stem cell transplantation hsct followed by infusion of bpx 501 t cells donor t cells transduced with ic9

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Administration of BPX-501 Cells Following Αβ T and B-Cell-Depleted HLA Haploidentical HSCT (haplo-HSCT) in Children with Acute Leukemias (AL)

Background Allogeneic HSCT is a well-established treatment for children with AL. For pts lacking a compatible matched related or unrelated donor, HLA-haplo-HSCT represents an alternative. Promising results were reported with selective depletion of αβ T and B cells (Locatelli, Blood 2017). PX-501 is an allogeneic product consisting of T cells modified to express the inducible caspase-9 (iC9) safety switch and truncated CD19 to allow monitoring and expansion of BPX-501 following transplant. BPX-501 provides broad virus and tumor-specific immunity; the safety switch provides the unique ability to promptly and durably resolve graft-versus-host disease (GvHD) symptoms following the administration of rimiducid. Aims Evaluate the safety and efficacy of BPX-501 in pediatric pts with AL by determining whether BPX-501 infusion can increase efficacy outcomes through an enhanced graft-versus-leukemic (GvL) effect, while maintaining a low risk of GvHD. Methods A subset of pts had high-risk ALs. BPX-501 was planned to be infused on day14±4 after the allograft with no post-transplant GvHD prophylaxis allowed. Pts who developed steroid-resistant GvHD could receive ≥1 dose of rimiducid. Results As of June 30, 2018, 100 pts with AL (described in Table 1) were efficacy evaluable. Median time for neutrophil and platelet engraftment was 16 and 12 days, respectively. Four pts (4.1%) experienced primary graft failure. Of 96 evaluable pts, 5 (3.1%) developed Grade III-IV aGvHD. Of 82 evaluable pts, 12 developed cGvHD (18.1%), with 3 moderate-severe. Rimiducid was administered to 10 pts. Best overall clinical response (CR/PR) post-rimiducid was 80% (8 pts). Among responding patients, 7 (87.5%) had a CR. Six (6.6%) pts died after transplantation. Efficacy outcomes in AL subsets are in Table 2. CD3+ and CD3+CD4+ T cells above 500 cells/ml were achieved by 180 and 270 days, respectively. IgA and IgM levels achieved normal values by 180 days. Conclusion BPX-501 following αβ-T and B-cell depleted haplo-HSCT represents a highly effective transplantation strategy for pediatric pts with AL. Rimiducid was an effective treatment for pts with steroid-resistant GvHD

Ethnomedicinal plants of Jodhpur District, Rajasthan used in herbal and folk remedies

The Jodhpur district a part of Thar Desert is very rich in medicinal plant wealth. The medicinal plants of this region have great potential to be used in drug and pharmaceutical industries. These herbal plants have been used by local people, tribal communities, vendors, native doctors such as Ojhas, Bhagats Bhopas and experts of Ayurvedic fields since long time in herbal and folk remedies. Kalbelia, Nats, Bhils, Raika, Bhopas, Banjara, Gadolia-Lohar, Saharia and Meena communities of this district have a rich knowledge of plants based traditional medicines. Ten ethnomedicinal plants like Cleome gynandra Linn., Clerodendrum phlomidis Linn., Cassia angustifolia Vahl., Echinops echinatus Roxb., Leucas aspera (Willd.) Spreng., Mimosa hamata Willd., Moringa oleifera Lamk., Pedalium murex Linn., Peganum harmala Linn., Sida cordifolia Linn. have been selected for this research work. The present investigation is aimed to create awareness about the ethnomedicinal value of the plants and their uses to draw the attention of pharmacologists, phytochemists and pharmaceuticals

Libraries or Fire Shrines? Reinterpreting the Function of ‘Annex Buildings’ in Khmer Śaiva Temples from the Prism of Early Śaivism

International audienc

Content analysis of sugar portrayal in online newspapers of Delhi, India

Background: The role of sugars on health and specifically on oral health is well evident in scientific literature. However, information regarding sugar portrayal in print media is quite limited. Objectives: To determine “Sugar Portrayal” in English newspapers (online version), a 1-year media content analysis of newspaper stories from Delhi (India) was conducted. Methods: Media content analysis was conducted by an online search for news stories in the two most popular Delhi English newspapers for daily and their Sunday equivalents. A total of 3648 newspaper articles and opinion pieces appearing over a period of 1 year (October 1, 2015, until September 30, 2016) were retrieved after entering selected “keywords.” The articles were reliably coded for overall frame and type of article. The data were entered in MS Excel and analyzed using SPSS version 21 (IBM Inc., Chicago, IL, USA). Results: It was inferred that the print media generally advertise sugar recipes and industry, invariably in state-wide context with either a negative or neutral slant. Although there was mention regarding benefits as well as harmful effects in the news stories, yet coverage often lacked detailed health information. Conclusions: The current study found out that there was relatively wider state-wide coverage of sugar, with very narrow focus on public health facts. More accurate information would permit the individuals to make more informed decisions regarding their own behavior